解剖学和形态学
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听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
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心理学,临床
abstract::In vitro exposures of isolated DNA to one of the two carcinogenic and mutagenic chemicals, diethylsulfate or dimethylsulfate, induces several kinds of physicochemical and morphological alterations. These changes are detectable by a variety of independent techniques. A fraction of DNA treated briefly with either of the...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.10.981
更新日期:1981-01-01 00:00:00
abstract::Aphidicolin is a specific inhibitor of DNA polymerase alpha. Its influence of DNA repair has been studied in both normal and excision deficient xeroderma pigmentosum cells exposed to u.v. irradiation at 254 nm. Single strand DNA breaks accumulated in u.v. irradiated normal cells when the inhibitor was present. Such br...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.8.795
更新日期:1981-01-01 00:00:00
abstract::The Raji human lymphoma line is able to remove O6-methylguanine (O6MeG) lesions introduced by treatment of cells with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The reaction has a rapid phase in which approximately 40% of the O6MeG is removed in the first 10 min. The capacity of cells for rapid O6MeG removal is limi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.12.1293
更新日期:1981-01-01 00:00:00
abstract::The effect of exposing mice to both a chemical carcinogen and leukemia virus with and without an inhibitor of DNA repair were compared. The data indicated that benzo[a]pyrene (BP) could exert a potentiating effect of Friend viral leukemogenesis in mice, which was dependent on the relative times of administration of th...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.1.1
更新日期:1981-01-01 00:00:00
abstract::Dehydroepiandrosterone (DHEA), a major adrenal secretory product in men and women, is a potent inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH). Long-term treatment with this steroid has previously been found to suppress spontaneous breast cancer development in C3H mice. DHEA is now shown to inhibit Ep...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.7.683
更新日期:1981-01-01 00:00:00
abstract::A quantitative relationship was established for 26 nitrosamines between their carcinogenic effectiveness in experimental animals and their mutagenic activity in a mammalian cell-mediated assay. Mutagenesis was measured in Chinese hamster V79 cells co-cultivated with primary rat hepatocytes, which are capable of activa...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.10.1075
更新日期:1981-01-01 00:00:00
abstract::Analysis of 24 h urine samples of rats administered N-nitrosodipropylamine (NDPA), N-nitroso-2-hydroxypropylpropylamine (NHPPA) or N-nitroso-2-oxopropylpropylamine (NOPPA) showed that the major excretion product in each case was the beta-glucuronide of NHPPA. This conjugate was shown to be present at levels of about 5...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.9.859
更新日期:1981-01-01 00:00:00
abstract::Six N-nitroso compounds (N-nitrosodimethylamine, N-nitrosodiethylamine, N-nitrosodi-n-propylamine, N-nitroso-N-methylurea, N-nitrosopyrrolidine, and N-nitrosodi-n-butylamine) were tested in rats for liver DNA damaging activity by the alkaline elution technique. On molar basis their DNA damaging potency was found to de...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.5.425
更新日期:1981-01-01 00:00:00
abstract::Following intraperitoneal administration of [3H] aflatoxin B1 (AFB1) to young adult male rats, there is rapid uptake of the carcinogen by the liver, the target organ for carcinogenesis, leading to DNA covalent binding. Acid hydrolysis of this DNA shows that after 2h, the major DNA adduct is trans 8,9-dihydro-8-(7-guan...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.9.787
更新日期:1980-09-01 00:00:00
abstract::This study analyzes the mechanism by which the tumor promoter 12-0-tetradecanoyl-phorbol 13-acetate (TPA) inhibits binding of epidermal growth factor (EGF) to its membrane receptors in HeLa cells. Kinetic studies indicate that inhibition of EGF binding occurs within a few minutes after exposure of cells to TPA; delaye...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.8.669
更新日期:1980-08-01 00:00:00
abstract::The metabolism of benzo[a]pyrene (BP) in cultured human epidermal keratinocytes was investigated using thin layer chromatography, high pressure liquid chromatography and cell-mediated mutagenesis assay. Epidermal keratinocytes were obtained from skin of normal subjects and all experiments were performed on primary cul...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.7.559
更新日期:1980-07-01 00:00:00
abstract::The ability of cytosolic 3-methylcholanthrene binding proteins from rat liver to interact with DNA was studied using DNA-cellulose chromatography. Two DNA binding fractions, eluting in 0.15 M KCl (peak 1) and 0.33 M KCl (peak 2), were observed on salt elution from a denatured DNA-cellulose column which had been incuba...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.6.481
更新日期:1980-06-01 00:00:00
abstract::Male Sprague-Dawley rats were fed a cube diet containing 2.51 mmol/kg 3'-hydroxymethyl-N,N-dimethyl-4-aminoazobenzene (3'-CH2OH-DAB) for a period of 1 or 3 months. (This is the molar equivalent of 0.06% 3'-Me-DAB in the diet). The oral administration of 3'-CH2OH-DAB for 3 months resulted in a high incidence of liver t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.6.533
更新日期:1980-06-01 00:00:00
abstract::DL-N-acetyl-N'-nitrosotryptophan (I) and its methyl ester (II), readily formed under mild conditions by the reaction of nitrite with N-acetyltryptophan or its methyl ester, are model compounds for the study of the nitrosation of alpha-amino acid side chains, considered relevant to possible role of nitrosation of pepti...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.6.523
更新日期:1980-06-01 00:00:00
abstract::In vivo incorporation of [3H] thymidine into DNA was determined in rats at 28 h after partial hepatectomy. Administration of nickel carbonyl (Ni(CO)4) at 2 or 4 h before sacrifice inhibited [3H] thymidine uptake into liver and kidney DNA. For example, in rats killed 4 h after i.v. injection of Ni(CO)4 (2 mg Ni/100 g),...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.4.297
更新日期:1980-04-01 00:00:00
abstract::The rates of reaction and the products formed when two vicinal diol-epoxides derived from benz(a)anthracene, anti-BA-3,4-diol 1,2-oxide (t-3,r-4-dihydroxy-t-1,2-oxy-1,2,3,4-tetrahydrobenz(a) anthracene)* and anti-BA-8,9-diol 10,11-oxide (r-8,t-9-dihydroxy-t-10,11-oxy-8,9,10,11-tetrahydrobenz(a)anthracene) reacted with...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.3.277
更新日期:1980-03-01 00:00:00
abstract::To elucidate the mechanism of metabolic activation of 3'-methyl-N,N-dimethyl-4-aminoazobenzene (3'-Me-DAB), the mutagenicity of its metabolites and some related azo compounds towards Salmonella typhimurium TA-98 and TA-100 was investigated. Mutagenicity of the metabolites, either N-demethylated or oxidized at the 3'-m...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.2.121
更新日期:1980-02-01 00:00:00
abstract::Female inbred C3H/St mice infected with the Bittner Milk Particle, develop mammary adenocarcinoma with 27% incidence if maintained on a Torula Yeast diet supplemented with 1 ppm of selenium (organically bound, in yeast). Animals switched from the 1 ppm Se diet to a diet containing only 0.15 ppm Se after reaching the a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.2.199
更新日期:1980-02-01 00:00:00
abstract::58 MCA Cl 16 is an oncogenic methylcholanthrene-transformed variant of the non-transformed mouse embryo fibroblast cell line, C3H/10T1/2 Cl 8. Using two different protocols, we have isolated six temperature-sensitive mutants from N-methyl-N'-nitro-N-nitrosoguanidine treated cultures of 58 MCA Cl 16. C3H/10T1/2 Cl 8, 5...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.12.1059
更新日期:1980-01-01 00:00:00
abstract::Mutagenicity assays were carried out in the Salmonella/microsome test, using five S. typhimurium his(-) strains (TA1535, TA1537, TA1538, TA98 and TA100), both in the presence and absence of post-mitochondrial preparations from Aroclor-induced rat livers and suitable co-factors. Seven oil dispersants showed a wide rang...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.1.51
更新日期:1980-01-01 00:00:00
abstract::The mutagenicities of 2-aminodipyrido [1,2-a:3',2'-d] imidazole (Glu-P-2, a mutagen obtained from pyrolysate of glutamic acid) and six methyl substituted derivatives of Glu-P-2 were tested with Salmonella typhimurium TA98 and TA100 with S-9 mix. Glu-P-1 (6-Me-Glu-P-2) was the strongest mutagen to TA98 and TA100. 3-Me-...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.11.889
更新日期:1980-01-01 00:00:00
abstract::The conformation of N-(deoxyguanosin-8-yl)-2-acetylaminofluorene and N-(deoxyguanosin-8-yl)-2-aminofluorene was investigated by 1H n.m.r. spectroscopy. There was rotation about the glycosyl bond and preference for either the anti or syn conformation depended on whether or not the 8-arylamino nitrogen was acetylated. T...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.11.955
更新日期:1980-01-01 00:00:00
abstract::The liver-derived human cell line, Hep G2, has high benzo[a]pyrene-metabolizing activity and converts benzo[a]pyrene to intermediates that are mutagenic and that bind to DNA. This cell line will be useful for studying metabolic activation of polycyclic aromatic hydrocarbons and other xenobiotics by human tissue and as...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.10.871
更新日期:1980-01-01 00:00:00